Sequence Detail

ID/Version

Q8K203 Q4ADY6 Q8CD85 Q8R3P4 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Endonuclease 8-like 3; EC=3.2.2.-; EC=4.2.99.18 {ECO:0000269|PubMed:20185759, ECO:0000269|PubMed:22065741, ECO:0000269|PubMed:22569481, ECO:0000269|PubMed:23305905, ECO:0000269|PubMed:23313161};AltName: Full=DNA glycosylase F

Provider

SWISS-PROT

Sequence

Polypeptide 606 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Neil3	nei like 3 (E. coli)	25	104	3	9

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:146662 Torisu K, et al., Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein. J Biochem. 2005 Dec;138(6):763-72
J:146867 Takao M, et al., Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant. Genes Cells. 2009 Feb;14(2):261-70
J:150370 Hildrestrand GA, et al., Expression patterns of Neil3 during embryonic brain development and neoplasia. BMC Neurosci. 2009;10:45
J:158756 Liu M, et al., The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4925-30
J:180177 Sejersted Y, et al., Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18802-7
J:196229 Regnell CE, et al., Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells. Cell Rep. 2012 Sep 27;2(3):503-10
J:199046 Rolseth V, et al., Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress. Biochim Biophys Acta. 2013 May;1833(5):1157-64