Sequence Detail

ID/Version

Q8K3H0 Q9CUW4 Q8BWZ8 Q8VCJ8 Q69ZJ9 Q3UJP7 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=DCC-interacting protein 13-alpha {ECO:0000305}; Short=Dip13-alpha {ECO:0000303|Ref.1};AltName: Full=Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 707 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Appl1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	74	100	4	18

Sequence references in MGI

J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:156351 Wang C, et al., Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells. J Biol Chem. 2009 Nov 13;284(46):31608-15
J:157577 Swan LE, et al., Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3511-6
J:226873 Mao L, et al., Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway. Cell Biosci. 2014;4(1):60
J:227340 Tan Y, et al., Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts. J Cell Physiol. 2016 May;231(5):1142-50
J:239200 Fu X, et al., Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB early endocytic trafficking and signaling from early endosomes. Mol Biol Cell. 2011 Oct;22(19):3684-98
J:268007 Yeo JC, et al., Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor 4 Signaling in Macrophages. Traffic. 2016 Sep;17(9):1014-26
J:268015 Yeo JC, et al., Rab31 and APPL2 enhance FcgammaR-mediated phagocytosis through PI3K/Akt signaling in macrophages. Mol Biol Cell. 2015 Mar 1;26(5):952-65
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89