Sequence Detail

ID/Version

Q8K4J6 Q642U1 (UniProt | EBI)

Last sequence update: 2003-06-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Myocardin-related transcription factor A {ECO:0000305}; Short=MRTF-A {ECO:0000303|PubMed:27304076};AltName: Full=Basic SAP coiled-coil transcription activator {ECO:0000303|PubMed:12019265};AltName: Full=MKL/myocardin-like protein 1;A

Provider

SWISS-PROT

Sequence

Polypeptide 964 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mrtfa	myocardin related transcription factor A	40	108	4	32

Sequence references in MGI

J:78258 Sasazuki T, et al., Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. J Biol Chem. 2002 Aug 9;277(32):28853-60
J:83853 Wang DZ, et al., Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14855-60
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:142795 Mouilleron S, et al., Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL. EMBO J. 2008 Dec 3;27(23):3198-208
J:150313 Brandt DT, et al., SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat Cell Biol. 2009 May;11(5):557-68
J:165431 Pawlowski R, et al., An actin-regulated importin alpha/beta-dependent extended bipartite NLS directs nuclear import of MRTF-A. EMBO J. 2010 Oct 20;29(20):3448-58
J:265603 Baarlink C, et al., Nuclear actin network assembly by formins regulates the SRF coactivator MAL. Science. 2013 May 17;340(6134):864-7
J:265605 Esnault C, et al., Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts. Genes Dev. 2014 May 1;28(9):943-58
J:265632 Vartiainen MK, et al., Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL. Science. 2007 Jun 22;316(5832):1749-52
J:265732 Miralles F, et al., Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell. 2003 May 2;113(3):329-42
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89