Sequence Detail

ID/Version

Q8K4L6 Q924I1 Q3TYZ5 D6C6N6 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Matrix extracellular phosphoglycoprotein {ECO:0000303|PubMed:11414762};AltName: Full=Osteoblast/osteocyte factor 45 {ECO:0000303|PubMed:12421822}; Short=OF45 {ECO:0000303|PubMed:12421822};AltName: Full=Osteoregulin {ECO:0000250|UniPr

Provider

SWISS-PROT

Sequence

Polypeptide 441 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mepe	matrix extracellular phosphoglycoprotein with ASARM motif (bone)	9	109	2	11

Sequence references in MGI

J:70223 Argiro L, et al., Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. Genomics. 2001 Jun 15;74(3):342-51
J:81218 Gowen LC, et al., Targeted Disruption of the Osteoblast/Osteocyte Factor 45 Gene (OF45) Results in Increased Bone Formation and Bone Mass. J Biol Chem. 2003 Jan 17;278(3):1998-2007
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:150696 Liu S, et al., Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia. J Am Soc Nephrol. 2005 Jun;16(6):1645-53
J:153409 Addison WN, et al., MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM. J Bone Miner Res. 2008 Oct;23(10):1638-49
J:186244 Staines KA, et al., MEPE is a novel regulator of growth plate cartilage mineralization. Bone. 2012 Sep;51(3):418-30
J:227060 Fujikawa K, et al., An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage. Eur J Histochem. 2015;59(3):2553
J:228153 Zelenchuk LV, et al., Age dependent regulation of bone-mass and renal function by the MEPE ASARM-motif. Bone. 2015 Oct;79:131-42
J:233764 Gullard A, et al., MEPE Localization in the Craniofacial Complex and Function in Tooth Dentin Formation. J Histochem Cytochem. 2016 Apr;64(4):224-36