Sequence Detail

ID/Version

Q8R000 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Organic solute transporter subunit alpha {ECO:0000303|PubMed:22535958}; Short=OST-alpha {ECO:0000303|PubMed:17650074};AltName: Full=Solute carrier family 51 subunit alpha;

Provider

SWISS-PROT

Sequence

Polypeptide 340 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc51a	solute carrier family 51, alpha subunit	22	98	3	8

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:106032 Dawson PA, et al., The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. J Biol Chem. 2005 Feb 25;280(8):6960-8
J:111079 Frankenberg T, et al., Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids. Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G912-22
J:126544 Li N, et al., Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter. Biochem J. 2007 Nov 1;407(3):363-72
J:132778 Rao A, et al., The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3891-6
J:187538 Christian WV, et al., beta-Subunit of the Ostalpha-Ostbeta organic solute transporter is required not only for heterodimerization and trafficking but also for function. J Biol Chem. 2012 Jun 15;287(25):21233-43
J:250040 Ballatori N, et al., OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology. 2005 Dec;42(6):1270-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89