Sequence Detail

ID/Version

Q8R0W6 Q9EQH8 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=NEDD4 family-interacting protein 1;AltName: Full=NEDD4 WW domain-binding protein 5;

Provider

SWISS-PROT

Sequence

Polypeptide 221 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ndfip1	Nedd4 family interacting protein 1	50	106	4	33

Sequence references in MGI

J:65663 Jolliffe CN, et al., Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase nedd4. Biochem J. 2000 Nov 1;351 Pt 3:557-65
J:75315 Harvey KF, et al., N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J Biol Chem. 2002 Mar 15;277(11):9307-17
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:116617 Oliver PM, et al., Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity. 2006 Dec;25(6):929-40
J:142420 Foot NJ, et al., Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood. 2008 Nov 15;112(10):4268-75
J:153079 Howitt J, et al., Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15489-94
J:206813 Altin JA, et al., Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2067-74
J:222650 Low LH, et al., Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response. J Biol Chem. 2015 Mar 13;290(11):7141-50
J:226892 Hammond VE, et al., Ndfip1 is required for the development of pyramidal neuron dendrites and spines in the neocortex. Cereb Cortex. 2014 Dec;24(12):3289-300
J:236888 O'Leary CE, et al., Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. Nat Commun. 2016 Apr 18;7:11226
J:243853 Layman AAK, et al., Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production. Sci Rep. 2017 Jan 04;7:39649
J:244459 Ramon HE, et al., The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility. Mucosal Immunol. 2011 May;4(3):314-24
J:244873 Kathania M, et al., Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7. J Immunol. 2015 Mar 01;194(5):2160-7