Sequence Detail

ID/Version

Q8R0X7 Q8C942 O54955 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Sphingosine-1-phosphate lyase 1 {ECO:0000305}; Short=S1PL; Short=SP-lyase 1; Short=SPL 1; Short=mSPL {ECO:0000303|PubMed:15522238}; EC=4.1.2.27 {ECO:0000269|PubMed:9464245};AltName: Full=Sphingosine-1-

Provider

SWISS-PROT

Sequence

Polypeptide 568 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sgpl1	sphingosine phosphate lyase 1	34	101	3	27

Sequence references in MGI

J:47955 Zhou J, et al., Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. Biochem Biophys Res Commun. 1998 Jan 26;242(3):502-7
J:93519 Ikeda M, et al., Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol. Biochem Biophys Res Commun. 2004 Dec 3;325(1):338-43
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:161192 Bektas M, et al., Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. J Biol Chem. 2010 Apr 2;285(14):10880-9
J:170381 Allende ML, et al., Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. J Biol Chem. 2011 Mar 4;286(9):7348-58
J:242929 Prasad R, et al., Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. J Clin Invest. 2017 Mar 01;127(3):942-953
J:242932 Lovric S, et al., Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest. 2017 Mar 01;127(3):912-928
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:319832 Mitroi DN, et al., SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. Autophagy. 2017 May 4;13(5):885-899