Sequence Detail

ID/Version

Q8R173 Q6EMK3 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Palmitoyltransferase ZDHHC3 {ECO:0000305}; EC=2.3.1.225 {ECO:0000269|PubMed:15229235, ECO:0000269|PubMed:16129400, ECO:0000269|PubMed:19001095, ECO:0000269|PubMed:23793055, ECO:0000269|PubMed:26487721};AltName: Full=Acyltransferase Z

Provider

SWISS-PROT

Sequence

Polypeptide 299 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Zdhhc3	zinc finger, DHHC domain containing 3	34	101	4	34

Sequence references in MGI

J:78577 Uemura T, et al., Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain. Biochem Biophys Res Commun. 2002 Aug 16;296(2):492-6
J:94875 Fukata M, et al., Identification of PSD-95 Palmitoylating Enzymes. Neuron. 2004 Dec 16;44(6):987-96
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:144763 Tsutsumi R, et al., Identification of G protein alpha subunit-palmitoylating enzyme. Mol Cell Biol. 2009 Jan;29(2):435-47
J:161679 Hines RM, et al., Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transport. J Biol Chem. 2010 Feb 12;285(7):4621-8
J:221517 Lemonidis K, et al., The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity. Mol Biol Cell. 2014 Dec 1;25(24):3870-83
J:237350 Murphy J, et al., Palmitoylation of Progressive Rod-Cone Degeneration (PRCD) Regulates Protein Stability and Localization. J Biol Chem. 2016 Oct 28;291(44):23036-23046
J:237763 Kilpatrick CL, et al., Dissociation of Golgi-associated DHHC-type Zinc Finger Protein (GODZ)- and Sertoli Cell Gene with a Zinc Finger Domain-beta (SERZ-beta)-mediated Palmitoylation by Loss of Function Analyses in Knock-out Mice. J Biol Chem. 2016 Dec 30;291(53):27371-27386
J:284989 Greaves J, et al., Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. J Biol Chem. 2008 Sep 5;283(36):25014-26
J:285004 Lai J, et al., Oligomerization of DHHC protein S-acyltransferases. J Biol Chem. 2013 Aug 2;288(31):22862-70
J:285006 Oku S, et al., In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. J Biol Chem. 2013 Jul 5;288(27):19816-29
J:285011 Fang C, et al., GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. J Neurosci. 2006 Dec 6;26(49):12758-68
J:287027 Greaves J, et al., Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1365-E1374
J:333223 Taruno A, et al., Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel. J Physiol. 2017 Sep 15;595(18):6121-6145
J:347143 Okui M, et al., Posttranslational regulation of CALHM1/3 channel: N-linked glycosylation and S-palmitoylation. FASEB J. 2021 May;35(5):e21527