Sequence Detail

ID/Version

Q8R331 Q9CZS6 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Zinc finger HIT domain-containing protein 1;AltName: Full=p18 Hamlet {ECO:0000250|UniProtKB:O43257};

Provider

SWISS-PROT

Sequence

Polypeptide 154 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Znhit1	zinc finger, HIT domain containing 1	26	107	3	12

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:150656 Yang Z, et al., Znhit1 causes cell cycle arrest and down-regulates CDK6 expression. Biochem Biophys Res Commun. 2009 Aug 14;386(1):146-52
J:160524 Cuadrado A, et al., Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation. EMBO J. 2010 Jun 16;29(12):2014-25
J:256297 Ye B, et al., Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2. Nat Commun. 2017 Nov 15;8(1):1518
J:276456 Zhao B, et al., Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation. Nat Commun. 2019 Mar 6;10(1):1071
J:299287 Sun S, et al., Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers. Leukemia. 2020 Dec;34(12):3348-3358
J:305946 Xu M, et al., The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Development. 2021 Apr 15;148(8):dev199026
J:323347 Shi Y, et al., Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy. JCI Insight. 2022 Mar 22;7(6):e148752
J:324706 Lu J, et al., Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation. Invest Ophthalmol Vis Sci. 2022 Apr 1;63(4):18
J:348727 Sun S, et al., Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression. Dev Cell. 2022 Apr 11;57(7):901-913.e4