Sequence Detail

ID/Version

Q8R420 Q3U3L4 (UniProt | EBI)

Last sequence update: 2011-06-28
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Phospholipid-transporting ATPase ABCA3 {ECO:0000305}; EC=7.6.2.1 {ECO:0000269|PubMed:17142808};AltName: Full=ATP-binding cassette sub-family A member 3 {ECO:0000305};AltName: Full=Xenobiotic-transporting ATPase ABCA3 {ECO:0000250|Uni

Provider

SWISS-PROT

Sequence

Polypeptide 1704 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Abca3	ATP-binding cassette, sub-family A member 3	57	120	3	14

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120296 Fitzgerald ML, et al., ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol. J Lipid Res. 2007 Mar;48(3):621-32
J:121155 Ban N, et al., ABCA3 as a lipid transporter in pulmonary surfactant biogenesis. J Biol Chem. 2007 Mar 30;282(13):9628-34
J:122736 Hammel M, et al., Targeted inactivation of the murine Abca3 gene leads to respiratory failure in newborns with defective lamellar bodies. Biochem Biophys Res Commun. 2007 Aug 10;359(4):947-951
J:124809 Cheong N, et al., ABCA3 is critical for lamellar body biogenesis in vivo. J Biol Chem. 2007 Aug 17;282(33):23811-7
J:274491 Beers MF, et al., Aberrant lung remodeling in a mouse model of surfactant dysregulation induced by modulation of the Abca3 gene. Ann Anat. 2017 Mar;210:135-146
J:278537 Besnard V, et al., Conditional deletion of Abca3 in alveolar type II cells alters surfactant homeostasis in newborn and adult mice. Am J Physiol Lung Cell Mol Physiol. 2010 May;298(5):L646-59
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297313 Mulugeta S, et al., Identification of LBM180, a lamellar body limiting membrane protein of alveolar type II cells, as the ABC transporter protein ABCA3. J Biol Chem. 2002 Jun 21;277(25):22147-55