Sequence Detail

ID/Version

Q8R4A3 Q9JK89 Q80VG9 Q8BP49 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Dapper homolog 1;AltName: Full=Dapper antagonist of catenin 1;AltName: Full=Frodo homolog;AltName: Full=MDpr1;AltName: Full=Thymus-expressed novel gene 3 protein;

Provider

SWISS-PROT

Sequence

Polypeptide 778 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dact1	dishevelled-binding antagonist of beta-catenin 1	69	119	3	13

Sequence references in MGI

J:80949 Cheyette BN, et al., Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. Dev Cell. 2002 Apr;2(4):449-61
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:111589 Fisher DA, et al., Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. Dev Dyn. 2006 Jul 31;235(9):2620-2630
J:111961 Hunter NL, et al., Vertebrate homologues of Frodo are dynamically expressed during embryonic development in tissues undergoing extensive morphogenetic movements. Dev Dyn. 2006 Jan;235(1):279-84
J:146933 Lagathu C, et al., Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network. Diabetes. 2009 Mar;58(3):609-19
J:152701 Suriben R, et al., Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet. 2009 Sep;41(9):977-85
J:159217 Okerlund ND, et al., Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain. J Neurosci. 2010 Mar 24;30(12):4362-8
J:161177 Wen J, et al., Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice. J Biol Chem. 2010 Apr 2;285(14):11023-30
J:175197 Wong HC, et al., Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell. 2003 Nov;12(5):1251-60
J:187547 Kivimae S, et al., All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. BMC Biochem. 2011;12:33
J:187575 Su Y, et al., The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling. FASEB J. 2007 Mar;21(3):682-90