Sequence Detail

ID/Version

Q8R4E9 Q8BUQ1 Q8BX29 Q8R4E8 Q8R3V0 (UniProt | EBI)

Last sequence update: 2002-06-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=DNA replication factor Cdt1;AltName: Full=Double parked homolog; Short=DUP;AltName: Full=Retroviral insertion site 2 protein;

Provider

SWISS-PROT

Sequence

Polypeptide 557 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cdt1	chromatin licensing and DNA replication factor 1	37	104	3	3

Sequence references in MGI

J:75006 Arentson E, et al., Oncogenic potential of the DNA replication licensing protein CDT1. Oncogene. 2002 Feb 14;21(8):1150-8
J:79742 Yanagi K, et al., Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. J Biol Chem. 2002 Oct 25;277(43):40871-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114148 Sugimoto N, et al., Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. J Biol Chem. 2004 May 7;279(19):19691-7
J:116246 Lee C, et al., Structural basis for inhibition of the replication licensing factor Cdt1 by geminin. Nature. 2004 Aug 19;430(7002):913-7
J:314075 Yanagi K, et al., Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development. J Biol Chem. 2005 May 20;280(20):19689-94