ID/Version |
|
||||||||||||||
Sequence description from provider |
RecName: Full=E3 ubiquitin-protein ligase RNF8 {ECO:0000255|HAMAP-Rule:MF_03067}; EC=2.3.2.27 {ECO:0000255|HAMAP-Rule:MF_03067};AltName: Full=ActA-interacting protein 37; Short=AIP37;AltName: Full=LaXp180;AltName: Full=RING finger protein | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
488
aa
|
||||||||||||||
Source | |||||||||||||||
Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
|
||||||||||||||
Sequence references in MGI |
J:66320
Pfeuffer T, et al., LaXp180, a mammalian ActA-binding protein, identified with the yeast two-hybrid system, co-localizes with intracellular Listeria monocytogenes. Cell Microbiol. 2000 Apr;2(2):101-14
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563 J:156522 Ramachandran S, et al., The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):809-14 J:159114 Lu LY, et al., RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Dev Cell. 2010 Mar 16;18(3):371-84 J:176962 Peuscher MH, et al., DNA-damage response and repair activities at uncapped telomeres depend on RNF8. Nat Cell Biol. 2011 Sep;13(9):1139-45 J:192582 Feng L, et al., The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol. 2012 Feb;19(2):201-6 J:242565 Gou LT, et al., Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell. 2017 Jun 01;169(6):1090-1104.e13 J:244705 Wu J, et al., Chfr and RNF8 synergistically regulate ATM activation. Nat Struct Mol Biol. 2011 Jun 26;18(7):761-8 J:245385 Rai R, et al., The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat Struct Mol Biol. 2011 Nov 20;18(12):1400-7 J:259113 Cardamone MD, et al., GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARgamma. Cell Rep. 2014 Jul 10;8(1):163-76 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/02/2024 MGI 6.24 |
![]() |
|