Sequence Detail

ID/Version

Q8VCK6 (UniProt | EBI)

Last sequence update: 2002-03-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Free fatty acid receptor 2;AltName: Full=G-protein coupled receptor 43;AltName: Full=Leukocyte-specific STAT-induced GPCR;

Provider

SWISS-PROT

Sequence

Polypeptide 330 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ffar2	free fatty acid receptor 2	45	101	5	17

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:138134 Ge H, et al., Activation of g protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free Fatty acids. Endocrinology. 2008 Sep;149(9):4519-26
J:153951 Maslowski KM, et al., Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature. 2009 Oct 29;461(7268):1282-6
J:157383 Sina C, et al., G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation. J Immunol. 2009 Dec 1;183(11):7514-22
J:160365 Zaibi MS, et al., Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids. FEBS Lett. 2010 Jun 3;584(11):2381-6
J:191508 Tolhurst G, et al., Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes. 2012 Feb;61(2):364-71
J:197123 Hudson BD, et al., Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3. J Biol Chem. 2012 Nov 30;287(49):41195-209
J:210918 Hong YH, et al., Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. Endocrinology. 2005 Dec;146(12):5092-9
J:211230 Hudson BD, et al., Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor. J Biol Chem. 2013 Jun 14;288(24):17296-312
J:211434 Kim MH, et al., Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology. 2013 Aug;145(2):396-406.e1-10