Sequence Detail

ID/Version

Q8VCW4 O89077 Q710D2 Q3TNR9 Q8R3D0 Q8CIK1 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Protein unc-93 homolog B1 {ECO:0000305}; Short=Unc-93B1;

Provider

SWISS-PROT

Sequence

Polypeptide 598 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Unc93b1	unc-93 homolog B1, TLR signaling regulator	41	100	3	12

Sequence references in MGI

J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105484 Tabeta K, et al., The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol. 2006 Feb;7(2):156-64
J:132643 Kim YM, et al., UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature. 2008 Mar 13;452(7184):234-8
J:149447 Fukui R, et al., Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. J Exp Med. 2009 Jun 8;206(6):1339-50
J:161113 Brinkmann MM, et al., The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol. 2007 Apr 23;177(2):265-75
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:304592 Ishida H, et al., Cryo-EM structures of Toll-like receptors in complex with UNC93B1. Nat Struct Mol Biol. 2021 Feb;28(2):173-180