Sequence Detail

ID/Version

Q8VCX5 Q8BL84 Q8BK07 Q8R1W0 (UniProt | EBI)

Last sequence update: 2002-03-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Calcium uptake protein 1, mitochondrial {ECO:0000305};AltName: Full=Calcium-binding atopy-related autoantigen 1 homolog {ECO:0000303|PubMed:21685888};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 477 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Micu1	mitochondrial calcium uptake 1	53	103	3	23

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:174847 De Stefani D, et al., A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature. 2011 Aug 18;476(7360):336-40
J:196299 Plovanich M, et al., MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. PLoS One. 2013;8(2):e55785
J:207459 Patron M, et al., MICU1 and MICU2 Finely Tune the Mitochondrial Ca(2+) Uniporter by Exerting Opposite Effects on MCU Activity. Mol Cell. 2014 Mar 6;53(5):726-37
J:236567 Antony AN, et al., MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration. Nat Commun. 2016 Mar 09;7:10955
J:238984 Liu JC, et al., MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload. Cell Rep. 2016 Aug 09;16(6):1561-73
J:248720 Vecellio Reane D, et al., A MICU1 Splice Variant Confers High Sensitivity to the Mitochondrial Ca(2+) Uptake Machinery of Skeletal Muscle. Mol Cell. 2016 Nov 17;64(4):760-773
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:347311 Roman B, et al., Loss of mitochondrial Ca(2+) uptake protein 3 impairs skeletal muscle calcium handling and exercise capacity. J Physiol. 2024 Jan;602(1):113-128
J:347326 Marchi S, et al., Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca(2+) levels and tumor growth. EMBO J. 2019 Jan 15;38(2)
J:347330 Tomar D, et al., MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca(2+) uniporter channel. Sci Signal. 2023 Apr 25;16(782):eabi8948