Sequence Detail

ID/Version

Q8VDK1 O88526 Q9R1N4 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Deaminated glutathione amidase {ECO:0000303|PubMed:28373563}; Short=dGSH amidase {ECO:0000303|PubMed:28373563}; EC=3.5.1.128 {ECO:0000269|PubMed:28373563};AltName: Full=Nitrilase homolog 1 {ECO:0000305};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 323 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nit1	nitrilase 1	6	103	3	14

Sequence references in MGI

J:58686 Pekarsky Y, et al., Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8744-9
J:115052 Semba S, et al., Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor. J Biol Chem. 2006 Sep 22;281(38):28244-53
J:149570 Zhang H, et al., Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells. Int Immunol. 2009 Jun;21(6):691-703
J:161261 Sun J, et al., Nit1 and Fhit tumor suppressor activities are additive. J Cell Biochem. 2009 Aug 15;107(6):1097-106
J:242138 Peracchi A, et al., Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3233-E3242
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89