Sequence Detail

ID/Version

Q8VDQ8 E9PXF5 Q9CXS5 Q9EQ18 Q9ERJ9 U5TP50 (UniProt | EBI)

Last sequence update: 2003-10-31
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=NAD-dependent protein deacetylase sirtuin-2; EC=2.3.1.286 {ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:17521387, ECO:0000269|PubMed:17574768, ECO:0000269|PubMed:17681146, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:3

Provider

SWISS-PROT

Sequence

Polypeptide 389 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sirt2	sirtuin 2	174	112	3	18

Sequence references in MGI

J:65632 Yang YH, et al., Cloning and characterization of two mouse genes with homology to the yeast sir2 gene. Genomics. 2000 Nov 1;69(3):355-69
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:124219 Suzuki K, et al., Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation. Neuroscience. 2007 Jul 13;147(3):599-612
J:129943 Jing E, et al., SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab. 2007 Aug;6(2):105-14
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:145263 Werner HB, et al., Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci. 2007 Jul 18;27(29):7717-30
J:175773 Maxwell MM, et al., The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS. Hum Mol Genet. 2011 Oct 15;20(20):3986-96
J:177468 Beirowski B, et al., Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E952-61
J:177486 Kim HS, et al., SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity. Cancer Cell. 2011 Oct 18;20(4):487-99
J:186147 Wang F, et al., Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. Oncogene. 2012 Mar 22;31(12):1546-57
J:195041 Serrano L, et al., The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev. 2013 Mar 15;27(6):639-53
J:209463 Zhang L, et al., Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis. FASEB J. 2014 Mar;28(3):1435-45
J:209483 Wang F, et al., SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol Biol Cell. 2009 Feb;20(3):801-8
J:209487 Southwood CM, et al., Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. Neurochem Res. 2007 Feb;32(2):187-95
J:210910 Wang F, et al., SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell. 2007 Aug;6(4):505-14
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:342004 Sincennes MC, et al., Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice. Nat Commun. 2021 May 31;12(1):3253