Sequence Detail

ID/Version

Q91V24 Q9JL36 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=ATP-binding cassette sub-family A member 7;

Provider

SWISS-PROT

Sequence

Polypeptide 2159 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Abca7	ATP-binding cassette, sub-family A member 7	68	103	3	19

Sequence references in MGI

J:60841 Schriml LM, et al., Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus. Genomics. 2000 Feb 15;64(1):24-31
J:70470 Broccardo C, et al., Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter. Cytogenet Cell Genet. 2001;92(3-4):264-70
J:96865 Kim WS, et al., Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. J Biol Chem. 2005 Feb 4;280(5):3989-95
J:112621 Jehle AW, et al., ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J Cell Biol. 2006 Aug 14;174(4):547-56
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:206915 Tanaka N, et al., Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7. J Lipid Res. 2010 Sep;51(9):2591-9
J:207821 Wang N, et al., ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux. J Biol Chem. 2003 Oct 31;278(44):42906-12
J:225870 Satoh K, et al., ATP-binding Cassette Transporter A7 (ABCA7) Loss of Function Alters Alzheimer Amyloid Processing. J Biol Chem. 2015 Oct 2;290(40):24152-65
J:231748 Sakae N, et al., ABCA7 Deficiency Accelerates Amyloid-beta Generation and Alzheimer's Neuronal Pathology. J Neurosci. 2016 Mar 30;36(13):3848-59
J:268026 Fu Y, et al., ABCA7 Mediates Phagocytic Clearance of Amyloid-beta in the Brain. J Alzheimers Dis. 2016 Sep 6;54(2):569-84
J:269558 Nowyhed HN, et al., ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content. Sci Rep. 2017 Jan 16;7:40273
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89