Sequence Detail

ID/Version

Q91V98 Q3UMV6 Q91ZV1 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Endosialin;AltName: Full=Tumor endothelial marker 1;AltName: CD_antigen=CD248;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 765 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd248	CD248 antigen, endosialin	18	105	4	9

Sequence references in MGI

J:71592 Carson-Walter EB, et al., Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res. 2001 Sep 15;61(18):6649-55
J:72180 Opavsky R, et al., Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo. J Biol Chem. 2001 Oct 19;276(42):38795-807
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:222506 Naylor AJ, et al., A differential role for CD248 (Endosialin) in PDGF-mediated skeletal muscle angiogenesis. PLoS One. 2014;9(9):e107146
J:284103 Hong YK, et al., Tumor Endothelial Marker 1 (TEM1/Endosialin/CD248) Enhances Wound Healing by Interacting with Platelet-Derived Growth Factor Receptors. J Invest Dermatol. 2019 Oct;139(10):2204-2214.e7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:343785 Benedet PO, et al., CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation. EBioMedicine. 2023 Dec 6;99:104906
J:344132 Cheng TL, et al., Role of tumor endothelial marker 1 (Endosialin/CD248) lectin-like domain in lipopolysaccharide-induced macrophage activation and sepsis in mice. Transl Res. 2021 Jun;232:150-162
J:344436 Kapopara PR, et al., CD248 enhances tissue factor procoagulant function, promoting arterial and venous thrombosis in mouse models. J Thromb Haemost. 2021 Aug;19(8):1932-1947