Sequence Detail

ID/Version

Q91WD5 Q3UJX7 Q3U5Y9 Q3TNA8 Q99L23 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; EC=7.1.1.2 {ECO:0000269|PubMed:26437605, ECO:0000269|PubMed:29887397, ECO:0000269|PubMed:31297047};AltName: Full=Complex I-49kD; Short=CI-49kD;AltName: Ful

Provider

SWISS-PROT

Sequence

Polypeptide 463 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ndufs2	NADH:ubiquinone oxidoreductase core subunit S2	48	101	3	24

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:266072 Arias-Mayenco I, et al., Acute O2 Sensing: Role of Coenzyme QH2/Q Ratio and Mitochondrial ROS Compartmentalization. Cell Metab. 2018 Jul 3;28(1):145-158.e4
J:266510 Fernandez-Aguera MC, et al., Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling. Cell Metab. 2015 Nov 3;22(5):825-37
J:281784 Cabello-Rivera D, et al., Mitochondrial Complex I Function Is Essential for Neural Stem/Progenitor Cells Proliferation and Differentiation. Front Neurosci. 2019;13:664
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297974 Yang Y, et al., LASS2 regulates hepatocyte steatosis by interacting with NDUFS2/OXPHOS related proteins. Biochem Biophys Res Commun. 2020 Jun 11;526(4):871-879
J:305996 Dunham-Snary KJ, et al., Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction. Circ Res. 2019 Jun 7;124(12):1727-1746
J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071