Sequence Detail

ID/Version

Q91WU6 Q3TC41 Q6EMK2 Q8K1H6 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Palmitoyltransferase ZDHHC7 {ECO:0000305}; EC=2.3.1.225 {ECO:0000269|PubMed:15603741, ECO:0000269|PubMed:18596047, ECO:0000269|PubMed:19001095, ECO:0000269|PubMed:23687301, ECO:0000269|PubMed:25253725, ECO:0000269|PubMed:28057756};Al

Provider

SWISS-PROT

Sequence

Polypeptide 308 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Zdhhc7	zinc finger, DHHC domain containing 7	46	100	3	8

Sequence references in MGI

J:94875 Fukata M, et al., Identification of PSD-95 Palmitoylating Enzymes. Neuron. 2004 Dec 16;44(6):987-96
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:144763 Tsutsumi R, et al., Identification of G protein alpha subunit-palmitoylating enzyme. Mol Cell Biol. 2009 Jan;29(2):435-47
J:221517 Lemonidis K, et al., The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity. Mol Biol Cell. 2014 Dec 1;25(24):3870-83
J:237763 Kilpatrick CL, et al., Dissociation of Golgi-associated DHHC-type Zinc Finger Protein (GODZ)- and Sertoli Cell Gene with a Zinc Finger Domain-beta (SERZ-beta)-mediated Palmitoylation by Loss of Function Analyses in Knock-out Mice. J Biol Chem. 2016 Dec 30;291(53):27371-27386
J:239061 Du K, et al., DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation. J Biol Chem. 2017 Feb 17;292(7):2979-2991
J:284989 Greaves J, et al., Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. J Biol Chem. 2008 Sep 5;283(36):25014-26
J:285006 Oku S, et al., In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. J Biol Chem. 2013 Jul 5;288(27):19816-29
J:285011 Fang C, et al., GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. J Neurosci. 2006 Dec 6;26(49):12758-68
J:287027 Greaves J, et al., Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1365-E1374
J:352412 Zhang N, et al., A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis. Nat Cell Biol. 2024 May;26(5):757-769