Sequence Detail

ID/Version

Q91X17 Q62285 Q3TP60 Q3TN64 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Uromodulin;AltName: Full=Tamm-Horsfall urinary glycoprotein; Short=THP;Contains: RecName: Full=Uromodulin, secreted form;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 642 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Umod	uromodulin	101	119	5	16

Sequence references in MGI

J:23126 Prasadan K, et al., Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein)--the most abundant protein in mammalian urine. Biochim Biophys Acta. 1995 Feb 21;1260(3):328-32
J:97228 Bates JM, et al., Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney Int. 2004 Mar;65(3):791-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:173004 Mo L, et al., Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation. Kidney Int. 2004 Sep;66(3):1159-66
J:243799 Brunati M, et al., The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin. Elife. 2015 Dec 17;4:e08887
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89