Sequence Detail

ID/Version

Q91X85 A0A0R4J0E9 (UniProt | EBI)

Last sequence update: 2024-10-02
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Choline/ethanolamine transporter FLVCR2 {ECO:0000305};AltName: Full=Calcium-chelate transporter {ECO:0000250|UniProtKB:Q9UPI3}; Short=CCT {ECO:0000250|UniProtKB:Q9UPI3};AltName: Full=Feline leukemia virus subgroup C receptor-related

Provider

SWISS-PROT

Sequence

Polypeptide 551 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Flvcr2	feline leukemia virus subgroup C cellular receptor 2	40	100	4	13

Sequence references in MGI

J:87761 Brasier G, et al., Novel hexad repeats conserved in a putative transporter with restricted expression in cell types associated with growth, calcium exchange and homeostasis. Exp Cell Res. 2004 Feb 1;293(1):31-42
J:287134 Santander N, et al., Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier. J Clin Invest. 2020 May 5;
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:294228 Kalailingam P, et al., Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome. J Clin Invest. 2020 Aug 3;130(8):4081-4093
J:301602 Li Y, et al., MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Nat Commun. 2020 Sep 24;11(1):4837
J:349932 Cater RJ, et al., Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature. 2024 May;629(8012):704-709
J:354126 Nguyen XTA, et al., MFSD7c functions as a transporter of choline at the blood-brain barrier. Cell Res. 2024 Mar;34(3):245-257