Sequence Detail

ID/Version

Q91XB0 Q3TAD7 Q9D6W2 Q9R1B0 (UniProt | EBI)

Last sequence update: 2004-05-24
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Three-prime repair exonuclease 1 {ECO:0000305}; EC=3.1.11.2 {ECO:0000269|PubMed:11279105, ECO:0000269|PubMed:15254239, ECO:0000269|PubMed:17293595, ECO:0000269|PubMed:17355961, ECO:0000269|PubMed:18780819};AltName: Full=3'-5' exonucl

Provider

SWISS-PROT

Sequence

Polypeptide 314 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trex1	three prime repair exonuclease 1	117	99	4	22

Sequence references in MGI

J:56273 Mazur DJ, et al., Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem. 1999 Jul 9;274(28):19655-60
J:92264 Morita M, et al., Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis. Mol Cell Biol. 2004 Aug;24(15):6719-27
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:121158 de Silva U, et al., The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering. J Biol Chem. 2007 Apr;282(14):10537-43
J:122553 Brucet M, et al., Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains. J Biol Chem. 2007 May 11;282(19):14547-57
J:141548 Yang YG, et al., Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell. 2007 Nov 30;131(5):873-86
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:145466 Stetson DB, et al., Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell. 2008 Aug 22;134(4):587-98
J:197521 Mazur DJ, et al., Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins. J Biol Chem. 2001 May 18;276(20):17022-9
J:207137 Pereira-Lopes S, et al., The exonuclease Trex1 restrains macrophage proinflammatory activation. J Immunol. 2013 Dec 15;191(12):6128-35
J:208222 Gehrke N, et al., Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. Immunity. 2013 Sep 19;39(3):482-95
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89