Sequence Detail

ID/Version

Q91YD4 Q5KTC0 (UniProt | EBI)

Last sequence update: 2016-11-02
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Transient receptor potential cation channel subfamily M member 2;AltName: Full=Long transient receptor potential channel 2; Short=LTrpC-2; Short=LTrpC2;AltName: Full=Transient receptor potential channel 7; Short=TrpC7

Provider

SWISS-PROT

Sequence

Polypeptide 1506 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trpm2	transient receptor potential cation channel, subfamily M, member 2	62	108	3	26

Sequence references in MGI

J:137259 Hara Y, et al., LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell. 2002 Jan;9(1):163-73
J:169329 Uchida K, et al., Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes. 2011 Jan;60(1):119-26
J:174397 Knowles H, et al., Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11578-83
J:178425 Sumoza-Toledo A, et al., Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release. FASEB J. 2011 Oct;25(10):3529-42
J:183834 Kashio M, et al., Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6745-50
J:220722 Manna PT, et al., TRPM2-mediated intracellular Zn2+ release triggers pancreatic beta-cell death. Biochem J. 2015 Mar 15;466(3):537-46
J:222577 Kashio M, et al., Redox Signal-mediated Enhancement of the Temperature Sensitivity of Transient Receptor Potential Melastatin 2 (TRPM2) Elevates Glucose-induced Insulin Secretion from Pancreatic Islets. J Biol Chem. 2015 May 8;290(19):12435-42
J:235274 Song K, et al., The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia. Science. 2016 Sep 23;353(6306):1393-1398
J:236608 Tan CH, et al., The TRPM2 ion channel is required for sensitivity to warmth. Nature. 2016 Aug 25;536(7617):460-3