Sequence Detail

ID/Version

Q91YT7 Q3TWU3 Q8BM70 Q8K325 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=YTH domain-containing family protein 2 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 579 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ythdf2	YTH N6-methyladenosine RNA binding protein 2	58	103	3	90

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:243747 Ivanova I, et al., The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence. Mol Cell. 2017 Sep 21;67(6):1059-1067.e4
J:276389 Li M, et al., Ythdf2-mediated m(6)A mRNA clearance modulates neural development in mice. Genome Biol. 2018 May 31;19(1):69
J:276493 Li Z, et al., Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018 Sep;28(9):904-917
J:276511 Wang H, et al., Loss of YTHDF2-mediated m(6)A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration. Cell Res. 2018 Oct;28(10):1035-1038
J:282659 Winkler R, et al., m(6)A modification controls the innate immune response to infection by targeting type I interferons. Nat Immunol. 2019 Feb;20(2):173-182
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:299108 Lasman L, et al., Context-dependent functional compensation between Ythdf m(6)A reader proteins. Genes Dev. 2020 Oct 1;34(19-20):1373-1391
J:302469 Huang T, et al., YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m(6)A/mRNA pathway. Cell Death Dis. 2020 Jan 20;11(1):37
J:350342 Liu J, et al., YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways. Cell Rep. 2020 Sep 8;32(10):108120