Sequence Detail

ID/Version

Q91ZR4 Q9D685 Q3U498 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase Nek8; EC=2.7.11.1;AltName: Full=Never in mitosis A-related kinase 8; Short=NimA-related protein kinase 8;

Provider

SWISS-PROT

Sequence

Polypeptide 698 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nek8	NIMA (never in mitosis gene a)-related expressed kinase 8	43	104	3	8

Sequence references in MGI

J:11885 Atala A, et al., Juvenile cystic kidneys (jck): a new mouse mutation which causes polycystic kidneys. Kidney Int. 1993 May;43(5):1081-5
J:79896 Liu S, et al., A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development. 2002 Dec;129(24):5839-46
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:149929 Sohara E, et al., Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J Am Soc Nephrol. 2008 Mar;19(3):469-76
J:150174 Otto EA, et al., NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis. J Am Soc Nephrol. 2008 Mar;19(3):587-92
J:175359 Mahjoub MR, et al., NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes. J Am Soc Nephrol. 2005 Dec;16(12):3485-9
J:219557 Yakulov TA, et al., Anks3 interacts with nephronophthisis proteins and is required for normal renal development. Kidney Int. 2015 Jun;87(6):1191-200