Sequence Detail

ID/Version

Q921E6 P97462 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Polycomb protein EED;

Provider

SWISS-PROT

Sequence

Polypeptide 441 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Eed	embryonic ectoderm development	47	113	3	107

Sequence references in MGI

J:35419 Schumacher A, et al., Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature. 1996 Sep 19;383(6597):250-3
J:41659 Denisenko ON, et al., The product of the murine homolog of the Drosophila extra sex combs gene displays transcriptional repressor activity. Mol Cell Biol. 1997 Aug;17(8):4707-17
J:70724 Wang J, et al., Imprinted X inactivation maintained by a mouse Polycomb group gene. Nat Genet. 2001 Aug;28(4):371-5
J:78736 Wang J, et al., The mouse PcG gene eed is required for Hox gene repression and extraembryonic development. Mamm Genome. 2002 Sep;13(9):493-503
J:82788 Plath K, et al., Role of histone H3 lysine 27 methylation in X inactivation. Science. 2003 Apr 4;300(5616):131-5
J:82790 Mager J, et al., Genome imprinting regulated by the mouse Polycomb group protein Eed. Nat Genet. 2003 Apr;33(4):502-7
J:90454 Mak W, et al., Reactivation of the paternal X chromosome in early mouse embryos. Science. 2004 Jan 30;303(5658):666-9
J:93084 Okamoto I, et al., Epigenetic dynamics of imprinted X inactivation during early mouse development. Science. 2004 Jan 30;303(5658):644-9
J:94241 Umlauf D, et al., Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nat Genet. 2004 Dec;36(12):1296-300
J:99186 Montgomery ND, et al., The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr Biol. 2005 May 24;15(10):942-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:121147 Kim SY, et al., Developmental regulation of Eed complex composition governs a switch in global histone modification in brain. J Biol Chem. 2007 Mar 30;282(13):9962-72
J:129406 Kalantry S, et al., The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nat Cell Biol. 2006 Feb;8(2):195-202
J:137700 Ura H, et al., STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells. J Biol Chem. 2008 Apr 11;283(15):9713-23
J:142193 Shen X, et al., EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 2008 Nov 21;32(4):491-502
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:157068 Walker E, et al., Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell. 2010 Feb 5;6(2):153-66
J:166345 Montgomery ND, et al., Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation. J Mol Biol. 2007 Dec 14;374(5):1145-57
J:200345 Denisenko O, et al., Point mutations in the WD40 domain of Eed block its interaction with Ezh2. Mol Cell Biol. 1998 Oct;18(10):5634-42
J:201058 Nguyen KD, et al., Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. Science. 2013 Sep 27;341(6153):1483-8
J:247419 Han Z, et al., Structural basis of EZH2 recognition by EED. Structure. 2007 Oct;15(10):1306-15
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89