Sequence Detail

ID/Version

Q921J2 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=GTP-binding protein Rheb; EC=3.6.5.- {ECO:0000250|UniProtKB:Q15382};AltName: Full=Ras homolog enriched in brain;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 184 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rheb	Ras homolog enriched in brain	53	99	4	41

Sequence references in MGI

J:170999 Goorden SM, et al., Rheb is essential for murine development. Mol Cell Biol. 2011 Apr;31(8):1672-8
J:180541 Zheng M, et al., Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol. 2011 Mar;13(3):263-72
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:338163 Garami A, et al., Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell. 2003 Jun;11(6):1457-66
J:338254 Buerger C, et al., Localization of Rheb to the endomembrane is critical for its signaling function. Biochem Biophys Res Commun. 2006 Jun 9;344(3):869-80