Sequence Detail

ID/Version

Q921L3 Q3TS11 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Calcium load-activated calcium channel {ECO:0000250|UniProtKB:Q9UM00}; Short=CLAC channel {ECO:0000250|UniProtKB:Q9UM00};AltName: Full=GEL complex subunit TMCO1 {ECO:0000305};AltName: Full=Transmembrane and coiled-coil domain-contain

Provider

SWISS-PROT

Sequence

Polypeptide 188 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tmco1	transmembrane and coiled-coil domains 1	24	97	3	21

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:233671 Wang QC, et al., TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel. Cell. 2016 Jun 2;165(6):1454-66
J:268917 Sun Z, et al., TMCO1 is essential for ovarian follicle development by regulating ER Ca(2+) store of granulosa cells. Cell Death Differ. 2018 Sep;25(9):1686-1701
J:273328 Li J, et al., TMCO1-mediated Ca(2+) leak underlies osteoblast functions via CaMKII signaling. Nat Commun. 2019 Apr 8;10(1):1589
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89