Sequence Detail

ID/Version

Q922S4 Q8K2U1 Q3TCR8 Q3TXZ6 (UniProt | EBI)

Last sequence update: 2018-03-28
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=cGMP-dependent 3',5'-cyclic phosphodiesterase {ECO:0000305|PubMed:21724846}; EC=3.1.4.17 {ECO:0000269|PubMed:21724846};AltName: Full=Cyclic GMP-stimulated phosphodiesterase; Short=CGS-PDE; Short=cGSPDE;

Provider

SWISS-PROT

Sequence

Polypeptide 939 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pde2a	phosphodiesterase 2A, cGMP-stimulated	122	104	2	13

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:177169 Martinez SE, et al., The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13260-5
J:177215 Acin-Perez R, et al., A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. J Biol Chem. 2011 Sep 2;286(35):30423-32
J:243434 Monterisi S, et al., PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling. Elife. 2017 May 02;6:e21374