Sequence Detail

ID/Version

Q924N4 A2AGK1 Q924N3 (UniProt | EBI)

Last sequence update: 2011-06-28
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Solute carrier family 12 member 6;AltName: Full=Electroneutral potassium-chloride cotransporter 3;AltName: Full=K-Cl cotransporter 3;

Provider

SWISS-PROT

Sequence

Polypeptide 1150 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc12a6	solute carrier family 12, member 6	44	99	3	18

Sequence references in MGI

J:55435 Mount DB, et al., Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. J Biol Chem. 1999 Jun 4;274(23):16355-62
J:76182 Pearson MM, et al., Localization of the K(+)-Cl(-) cotransporter, KCC3, in the central and peripheral nervous systems: expression in the choroid plexus, large neurons and white matter tracts. Neuroscience. 2001;103(2):481-91
J:79870 Howard HC, et al., The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nat Genet. 2002 Nov;32(3):384-92
J:138272 Salin-Cantegrel A, et al., HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3. Hum Mol Genet. 2008 Sep 1;17(17):2703-11
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:175181 Mercado A, et al., NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter. Am J Physiol Renal Physiol. 2005 Dec;289(6):F1246-61
J:259728 Kahle KT, et al., Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Sci Signal. 2016 Aug 2;9(439):ra77
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:335671 Liu S, et al., Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science. 2019 Oct 25;366(6464):505-508