Sequence Detail

ID/Version

Q924S7 (UniProt | EBI)

Last sequence update: 2001-12-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Sprouty-related, EVH1 domain-containing protein 2; Short=Spred-2;

Provider

SWISS-PROT

Sequence

Polypeptide 410 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Spred2	sprouty-related EVH1 domain containing 2	22	105	4	228

Sequence references in MGI

J:70801 Wakioka T, et al., Spred is a Sprouty-related suppressor of Ras signalling. Nature. 2001 Aug 9;412(6847):647-51
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100826 Bundschu K, et al., Gene disruption of Spred-2 causes dwarfism. J Biol Chem. 2005 Aug 5;280(31):28572-80
J:108170 Engelhardt CM, et al., Expression and subcellular localization of Spred proteins in mouse and human tissues. Histochem Cell Biol. 2004 Dec;122(6):527-38
J:130605 Chandramouli S, et al., Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. J Biol Chem. 2008 Jan 18;283(3):1679-91
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:248366 Lemonidis K, et al., Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase. J Biol Chem. 2017 Oct 20;292(42):17190-17202
J:287032 Zhao G, et al., Negative regulation of TGFbeta-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists. Exp Eye Res. 2015 Mar;132:9-16
J:287039 Zhao G, et al., Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred. Exp Eye Res. 2018 May;170:148-159
J:325031 Motta M, et al., SPRED2 loss-of-function causes a recessive Noonan syndrome-like phenotype. Am J Hum Genet. 2021 Nov 4;108(11):2112-2129