Sequence Detail

ID/Version

Q924X6 Q921B6 Q8CAK9 Q8CDF5 (UniProt | EBI)

Last sequence update: 2004-05-10
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Low-density lipoprotein receptor-related protein 8; Short=LRP-8;AltName: Full=Apolipoprotein E receptor 2;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 996 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lrp8	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	68	112	3	19

Sequence references in MGI

J:55691 Trommsdorff M, et al., Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell. 1999 Jun 11;97(6):689-701
J:63942 Stockinger W, et al., The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2. J Biol Chem. 2000 Aug 18;275(33):25625-32
J:70122 Brandes C, et al., Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha 2-macroglobulin. J Biol Chem. 2001 Jun 22;276(25):22160-9
J:70296 Kim HJ, et al., Evolution of the apolipoprotein E receptor 2 gene by exon loss. J Biochem. 1998 Aug;124(2):451-6
J:78545 Stockinger W, et al., The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor. EMBO J. 2002 Aug 15;21(16):4259-67
J:84102 Andersen OM, et al., Essential role of the apolipoprotein E receptor-2 in sperm development. J Biol Chem. 2003 Jun 27;278(26):23989-95
J:133662 Olson GE, et al., Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells. J Biol Chem. 2008 Mar 14;283(11):6854-60
J:142541 Fish KN, et al., Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse. Neurobiol Dis. 2008 Dec;32(3):391-401
J:266110 Tavazoie MF, et al., LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Cell. 2018 Feb 8;172(4):825-840.e18
J:273584 Sakaguchi N, et al., Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons. Neurosci Res. 2003 Feb;45(2):219-24
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89