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Sequence Detail
ID/Version
Q925H0 Q5SUU2 Q61203 (UniProt | EBI) Last sequence update: 2001-12-01
Last annotation update: 2024-07-24
Sequence
description
from provider
RecName: Full=Acid-sensing ion channel 2; Short=ASIC2;AltName: Full=Amiloride-sensitive brain sodium channel;AltName: Full=Amiloride-sensitive cation channel 1, neuronal;AltName: Full=Brain sodium channel 1 {ECO:0000303|PubMed:11306621}; S
Provider SWISS-PROT
Sequence
Polypeptide 512 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Asic2 acid-sensing ion channel 2 57 100 3 18
Sequence references in MGI J:44171 Lingueglia E, et al., A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J Biol Chem. 1997 Nov 21;272(47):29778-83
J:68839 Garcia-Anoveros J, et al., Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons. J Neurosci. 2001 Apr 15;21(8):2678-86
J:90117 Ettaiche M, et al., Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration. J Neurosci. 2004 Feb 4;24(5):1005-12
J:96521 Peng BG, et al., Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice. J Neurosci. 2004 Nov 10;24(45):10167-75
J:105150 McIlwrath SL, et al., The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability. Neuroscience. 2005;131(2):499-511
J:188623 Brand J, et al., A stomatin dimer modulates the activity of acid-sensing ion channels. EMBO J. 2012 Aug 29;31(17):3635-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory