Sequence Detail

ID/Version

Q99J21 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Mucolipin-1 {ECO:0000305};AltName: Full=Mucolipidin;AltName: Full=Transient receptor potential-mucolipin 1; Short=TRPML1 {ECO:0000303|PubMed:27623384};

Provider

SWISS-PROT

Sequence

Polypeptide 580 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mcoln1	mucolipin 1	65	100	4	9

Sequence references in MGI

J:75410 Falardeau JL, et al., Cloning and characterization of the mouse Mcoln1 gene reveals an alternatively spliced transcript not seen in humans. BMC Genomics. 2002;3(1):3
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:127446 Xu H, et al., Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18321-6
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:220315 Wang W, et al., Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1373-81
J:250436 Chen Q, et al., Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature. 2017 Oct 19;550(7676):415-418
J:289081 Krishna S, et al., PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment. Dev Cell. 2016 Sep 12;38(5):536-47
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:347339 Dong XP, et al., The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature. 2008 Oct 16;455(7215):992-6