Sequence Detail

ID/Version

Q99JB6 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Forkhead box protein P3;AltName: Full=Scurfin;Contains: RecName: Full=Forkhead box protein P3, C-terminally processed;Contains: RecName: Full=Forkhead box protein P3 41 kDa form;

Provider

SWISS-PROT

Sequence

Polypeptide 429 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Foxp3	forkhead box P3	176	105	4	48

Sequence references in MGI

J:66695 Brunkow ME, et al., Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001 Jan;27(1):68-73
J:97353 Bettelli E, et al., Foxp3 interacts with nuclear factor of activated T cells and NF-{kappa}B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5138-43
J:116306 Chae WJ, et al., The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9631-6
J:121433 Ono M, et al., Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature. 2007 Apr 5;446(7136):685-9
J:136164 Zhou L, et al., TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 2008 May 8;453(7192):236-40
J:151916 Pan F, et al., Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science. 2009 Aug 28;325(5944):1142-6
J:208225 Chen Z, et al., The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity. 2013 Aug 22;39(2):272-85