Sequence Detail

ID/Version

Q99JH7 Q544R0 A0A4P8DYG6 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Calsyntenin-3 {ECO:0000303|PubMed:12498782}; Short=Cst-3 {ECO:0000303|PubMed:24613359};AltName: Full=Alcadein-beta {ECO:0000303|PubMed:24094106};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 956 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Clstn3	calsyntenin 3	67	100	3	22

Sequence references in MGI

J:80943 Hintsch G, et al., The calsyntenins-a family of postsynaptic membrane proteins with distinct neuronal expression patterns. Mol Cell Neurosci. 2002 Nov;21(3):393-409
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113428 Konecna A, et al., Calsyntenin-1 docks vesicular cargo to kinesin-1. Mol Biol Cell. 2006 Aug;17(8):3651-63
J:201987 Pettem KL, et al., The Specific alpha-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development. Neuron. 2013 Oct 2;80(1):113-28
J:211830 Um JW, et al., Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep. 2014 Mar 27;6(6):1096-109
J:283355 Zeng X, et al., Innervation of thermogenic adipose tissue via a calsyntenin 3beta-S100b axis. Nature. 2019 May;569(7755):229-235
J:291190 Kim H, et al., Calsyntenin-3 interacts with both alpha- and beta-neurexins in the regulation of excitatory synaptic innervation in specific Schaffer collateral pathways. J Biol Chem. 2020 Jul 3;295(27):9244-9262
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:293885 Kim SJ, et al., Neural regulation of energy and bone homeostasis by the synaptic adhesion molecule Calsyntenin-3. Exp Mol Med. 2020 May;52(5):793-803
J:311243 Teafatiller T, et al., Upregulation of Vitamin C Transporter Functional Expression in 5xFAD Mouse Intestine. Nutrients. 2021 Feb 14;13(2)
J:326433 Liu Z, et al., Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum. Elife. 2022 Apr 14;11:e70664
J:329050 Mori K, et al., Loss of calsyntenin paralogs disrupts interneuron stability and mouse behavior. Mol Brain. 2022 Mar 12;15(1):23
J:333997 Qian K, et al., CLSTN3beta enforces adipocyte multilocularity to facilitate lipid utilization. Nature. 2023 Jan;613(7942):160-168