Sequence Detail

ID/Version

Q99KD6 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Cytochrome c oxidase subunit 7A2-like, mitochondrial {ECO:0000305};AltName: Full=Supercomplex assembly factor 1 {ECO:0000303|PubMed:34616041};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 113 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cox7a2l	cytochrome c oxidase subunit 7A2 like	9	98	3	16

Sequence references in MGI

J:199458 Lapuente-Brun E, et al., Supercomplex assembly determines electron flux in the mitochondrial electron transport chain. Science. 2013 Jun 28;340(6140):1567-70
J:215964 Ikeda K, et al., A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle. Nat Commun. 2013;4:2147
J:219636 Mourier A, et al., The respiratory chain supercomplex organization is independent of COX7a2l isoforms. Cell Metab. 2014 Dec 2;20(6):1069-75
J:238928 Perez-Perez R, et al., COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation. Cell Rep. 2016 Aug 30;16(9):2387-98
J:241319 Cogliati S, et al., Mechanism of super-assembly of respiratory complexes III and IV. Nature. 2016 Nov 24;539(7630):579-582
J:251032 Davoudi M, et al., COX7A2L/SCAFI and Pre-Complex III Modify Respiratory Chain Supercomplex Formation in Different Mouse Strains with a Bcs1l Mutation. PLoS One. 2016;11(12):e0168774
J:278383 Balsa E, et al., ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2alpha Axis. Mol Cell. 2019 Jun 6;74(5):877-890.e6
J:339735 Calvo E, et al., Functional role of respiratory supercomplexes in mice: SCAF1 relevance and segmentation of the Q(pool). Sci Adv. 2020 Jun;6(26):eaba7509
J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071
J:357966 Vercellino I, et al., Structure and assembly of the mammalian mitochondrial supercomplex CIII2CIV. Nature. 2021 Oct;598(7880):364-367