Sequence Detail

ID/Version

Q99MT6 Q4V9V9 (UniProt | EBI)

Last sequence update: 2009-09-22
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Succinate receptor 1;AltName: Full=G-protein coupled receptor 91;

Provider

SWISS-PROT

Sequence

Polypeptide 317 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sucnr1	succinate receptor 1	23	97	2	14

Sequence references in MGI

J:68335 Wittenberger T, et al., An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. J Mol Biol. 2001 Mar 30;307(3):799-813
J:143337 Rubic T, et al., Triggering the succinate receptor GPR91 on dendritic cells enhances immunity. Nat Immunol. 2008 Nov;9(11):1261-9
J:236624 Littlewood-Evans A, et al., GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis. J Exp Med. 2016 Aug 22;213(9):1655-62
J:262493 Lei W, et al., Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proc Natl Acad Sci U S A. 2018 May 22;115(21):5552-5557
J:282660 Keiran N, et al., SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity. Nat Immunol. 2019 May;20(5):581-592
J:296826 Reddy A, et al., pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise. Cell. 2020 Oct 1;183(1):62-75.e17
J:334888 Villanueva-Carmona T, et al., SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression. Cell Metab. 2023 Apr 4;35(4):601-619.e10