Sequence Detail

ID/Version

Q99NH8 Q8CGK4 Q8CIA6 Q99NH9 Q9JL34 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Triggering receptor expressed on myeloid cells 2; Short=TREM-2;AltName: Full=Triggering receptor expressed on monocytes 2;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 227 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trem2	triggering receptor expressed on myeloid cells 2	212	103	2	38

Sequence references in MGI

J:64954 Bouchon A, et al., Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000 May 15;164(10):4991-5
J:68104 Daws MR, et al., Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur J Immunol. 2001 Mar;31(3):783-91
J:96626 Takahashi K, et al., Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med. 2005 Feb 21;201(4):647-57
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:110786 Takegahara N, et al., Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nat Cell Biol. 2006 Jun;8(6):615-22
J:215678 Kleinberger G, et al., TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med. 2014 Jul 2;6(243):243ra86
J:239381 Zheng H, et al., TREM2 Promotes Microglial Survival by Activating Wnt/beta-Catenin Pathway. J Neurosci. 2017 Feb 15;37(7):1772-1784
J:242126 Kleinberger G, et al., The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. EMBO J. 2017 Jul 03;36(13):1837-1853
J:242830 Ulland TK, et al., TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell. 2017 Aug 10;170(4):649-663.e13
J:243588 Mazaheri F, et al., TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. EMBO Rep. 2017 Jul;18(7):1186-1198
J:258167 Helming L, et al., Essential role of DAP12 signaling in macrophage programming into a fusion-competent state. Sci Signal. 2008 Oct 28;1(43):ra11
J:260524 Zhao Y, et al., TREM2 Is a Receptor for beta-Amyloid that Mediates Microglial Function. Neuron. 2018 Mar 7;97(5):1023-1031.e7
J:264653 Cheng-Hathaway PJ, et al., The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease. Mol Neurodegener. 2018 Jun 1;13(1):29
J:266671 Sayed FA, et al., Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10172-10177
J:270386 Sudom A, et al., Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. J Biol Chem. 2018 Aug 10;293(32):12634-12646
J:272738 Filipello F, et al., The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity. Immunity. 2018 May 15;48(5):979-991.e8
J:273253 Linnartz-Gerlach B, et al., TREM2 triggers microglial density and age-related neuronal loss. Glia. 2019 Mar;67(3):539-550
J:273509 Wu R, et al., TREM2 protects against cerebral ischemia/reperfusion injury. Mol Brain. 2017 Jun 7;10(1):20
J:273534 Thornton P, et al., TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant. EMBO Mol Med. 2017 Oct;9(10):1366-1378
J:273549 Humphrey MB, et al., TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. J Bone Miner Res. 2006 Feb;21(2):237-45
J:274782 Cantoni C, et al., TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta Neuropathol. 2015 Mar;129(3):429-47
J:304584 Li C, et al., TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-kappaB signaling. Cell Biol Int. 2019 Apr;43(4):360-372