Sequence Detail

ID/Version

Q99PI8 Q80WQ1 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Reticulon-4 receptor;AltName: Full=Nogo receptor; Short=NgR {ECO:0000303|PubMed:15504325};AltName: Full=Nogo-66 receptor {ECO:0000303|PubMed:15504325};AltName: Full=Nogo66 receptor-1 {ECO:0000303|PubMed:22406547}; Short=NgR1

Provider

SWISS-PROT

Sequence

Polypeptide 473 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rtn4r	reticulon 4 receptor	55	110	3	29

Sequence references in MGI

J:68902 Fournier AE, et al., Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature. 2001 Jan 18;409(6818):341-6
J:94754 Kim JE, et al., Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron. 2004 Oct 28;44(3):439-51
J:96121 Zheng B, et al., Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1205-10
J:138580 Williams G, et al., Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. J Biol Chem. 2008 Jun 13;283(24):16641-52
J:143056 Budel S, et al., Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. J Neurosci. 2008 Dec 3;28(49):13161-72
J:161875 Mathis C, et al., Nogo-a regulates neural precursor migration in the embryonic mouse cortex. Cereb Cortex. 2010 Oct;20(10):2380-90
J:182292 Wills ZP, et al., The nogo receptor family restricts synapse number in the developing hippocampus. Neuron. 2012 Feb 9;73(3):466-81
J:191258 Dickendesher TL, et al., NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat Neurosci. 2012 May;15(5):703-12
J:223638 Worter V, et al., Inhibitory activity of myelin-associated glycoprotein on sensory neurons is largely independent of NgR1 and NgR2 and resides within Ig-Like domains 4 and 5. PLoS One. 2009;4(4):e5218
J:224729 Nakaya N, et al., Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth. J Biol Chem. 2012 Oct 26;287(44):37171-84
J:230364 Liu BP, et al., Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science. 2002 Aug 16;297(5584):1190-3
J:238442 Palandri A, et al., Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75(NTR) receptor-mediated activation of RhoA signaling pathways. Cell Death Dis. 2015 Sep 03;6:e1876
J:238817 Yoo SW, et al., Agenesis of the corpus callosum in Nogo receptor deficient mice. J Comp Neurol. 2017 Feb 01;525(2):291-301