Sequence Detail

ID/Version

Q99PJ2 Q8CGI2 Q3U2G3 Q8C508 Q8C700 Q99PQ4 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase TRIM8; EC=2.3.2.27;AltName: Full=Glioblastoma-expressed RING finger protein;AltName: Full=RING finger protein 27;AltName: Full=RING-type E3 ubiquitin transferase TRIM8 {ECO:0000305};AltName: Full=Tripartit

Provider

SWISS-PROT

Sequence

Polypeptide 551 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trim8	tripartite motif-containing 8	39	102	4	30

Sequence references in MGI

J:66497 Vincent SR, et al., A novel RING finger-B box-coiled-coil protein, GERP. Biochem Biophys Res Commun. 2000 Dec 20;279(2):482-6
J:69273 Reymond A, et al., The tripartite motif family identifies cell compartments. EMBO J. 2001 May 1;20(9):2140-51
J:79351 Toniato E, et al., TRIM8/GERP RING Finger Protein Interacts with SOCS-1. J Biol Chem. 2002 Oct 4;277(40):37315-22
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:177748 Okumura F, et al., TRIM8 regulates Nanog via Hsp90beta-mediated nuclear translocation of STAT3 in embryonic stem cells. Biochim Biophys Acta. 2011 Oct;1813(10):1784-92
J:251270 Ye W, et al., TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction. J Immunol. 2017 Sep 1;199(5):1856-1864
J:303068 Tao Q, et al., Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways. Int J Biol Sci. 2019;15(8):1618-1629