Sequence Detail

ID/Version

Q9CQJ4 O35729 Q8C1X8 O35699 Q4FJV5 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase RING2; EC=2.3.2.27 {ECO:0000269|PubMed:15525528, ECO:0000269|PubMed:22325148, ECO:0000269|PubMed:24980959};AltName: Full=RING finger protein 1B; Short=RING1b;AltName: Full=RING finger protein 2;Alt

Provider

SWISS-PROT

Sequence

Polypeptide 336 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rnf2	ring finger protein 2	69	112	3	42

Sequence references in MGI

J:43598 Schoorlemmer J, et al., Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO J. 1997 Oct 1;16(19):5930-42
J:65786 Garcia E, et al., RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J. 1999 Jun 15;18(12):3404-18
J:79851 Suzuki M, et al., Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development. 2002 Sep;129(18):4171-83
J:94519 de Napoles M, et al., Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell. 2004 Nov;7(5):663-76
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100027 Isono K, et al., Mammalian polyhomeotic homologues phc2 and phc1 act in synergy to mediate polycomb repression of hox genes. Mol Cell Biol. 2005 Aug;25(15):6694-706
J:119024 Buchwald G, et al., Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. EMBO J. 2006 Jun 7;25(11):2465-74
J:172960 Neira JL, et al., The transcriptional repressor RYBP is a natively unfolded protein which folds upon binding to DNA. Biochemistry. 2009 Feb 17;48(6):1348-60
J:186106 Tavares L, et al., RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. Cell. 2012 Feb 17;148(4):664-78
J:203428 Frangini A, et al., The aurora B kinase and the polycomb protein ring1B combine to regulate active promoters in quiescent lymphocytes. Mol Cell. 2013 Sep 12;51(5):647-61
J:243420 Almeida M, et al., PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation. Science. 2017 Jun 09;356(6342):1081-1084
J:253631 Omori Y, et al., Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity. Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8264-E8273
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:314082 Xia P, et al., RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy. Cell Res. 2014 Aug;24(8):943-58