Sequence Detail

ID/Version

Q9CUS9 E9QP88 Q8R597 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Signal peptide peptidase-like 3 {ECO:0000250|UniProtKB:Q8TCT6}; Short=SPP-like 3 {ECO:0000250|UniProtKB:Q8TCT6}; EC=3.4.23.-;AltName: Full=Intramembrane protease 2 {ECO:0000250|UniProtKB:Q8TCT6}; Short=IMP-2 {ECO:0000

Provider

SWISS-PROT

Sequence

Polypeptide 384 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sppl3	signal peptide peptidase 3	35	100	3	81

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
J:216762 Voss M, et al., Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. EMBO J. 2014 Dec 17;33(24):2890-905
J:221514 Makowski SL, et al., A protease-independent function for SPPL3 in NFAT activation. Mol Cell Biol. 2015 Jan;35(2):451-67
J:238258 Kuhn PH, et al., Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways. Mol Cell Proteomics. 2015 Jun;14(6):1584-98