Sequence Detail

ID/Version

Q9CWQ0 Q6PAC5 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Diphthine methyl ester synthase; EC=2.1.1.314;AltName: Full=Diphthamide biosynthesis methyltransferase;

Provider

SWISS-PROT

Sequence

Polypeptide 281 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dph5	diphthamide biosynthesis 5	8	96	3	14

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:131468 Liu S, et al., Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. Mol Cell Biol. 2004 Nov;24(21):9487-97
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:327285 Shankar SP, et al., A novel DPH5-related diphthamide-deficiency syndrome causing embryonic lethality or profound neurodevelopmental disorder. Genet Med. 2022 Jul;24(7):1567-1582