Sequence Detail

ID/Version

Q9CWR8 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=DNA (cytosine-5)-methyltransferase 3-like;

Provider

SWISS-PROT

Sequence

Polypeptide 421 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dnmt3l	DNA methyltransferase 3-like	46	137	5	55

Sequence references in MGI

J:68934 Aapola U, et al., Isolation and initial characterization of the mouse Dnmt3l gene. Cytogenet Cell Genet. 2001;92(1-2):122-6
J:73452 Bourc'his D, et al., Dnmt3L and the establishment of maternal genomic imprints. Science. 2001 Dec 21;294(5551):2536-9
J:92661 Bourc'his D, et al., Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature. 2004 Sep 2;431(7004):96-9
J:98706 Gowher H, et al., Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L. J Biol Chem. 2005 Apr 8;280(14):13341-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:173049 Jurkowska RZ, et al., Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Res. 2008 Dec;36(21):6656-63
J:206847 Neri F, et al., Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs. Cell. 2013 Sep 26;155(1):121-34
J:295943 Zoch A, et al., SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation. Nature. 2020 Aug;584(7822):635-639