Sequence Detail

ID/Version

Q9CXY1 Q99K00 Q3TDC4 (UniProt | EBI)

Last sequence update: 2007-04-03
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Endosomal/lysosomal proton channel TMEM175 {ECO:0000305};AltName: Full=Potassium channel TMEM175 {ECO:0000305};AltName: Full=Transmembrane protein 175 {ECO:0000303|PubMed:26317472}; Short=mTMEM175 {ECO:0000303|PubMed:26317472};

Provider

SWISS-PROT

Sequence

Polypeptide 499 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tmem175	transmembrane protein 175	30	96	3	16

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:225577 Cang C, et al., TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function. Cell. 2015 Aug 27;162(5):1101-12
J:304120 Wie J, et al., A growth-factor-activated lysosomal K(+) channel regulates Parkinson's pathology. Nature. 2021 Mar;591(7850):431-437
J:335793 Hu M, et al., Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes. Cell. 2022 Jun 23;185(13):2292-2308.e20