Sequence Detail

ID/Version

Q9CYP7 Q3U2A0 (UniProt | EBI)

Last sequence update: 2001-04-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Sestrin-3 {ECO:0000305}; EC=1.11.1.- {ECO:0000250|UniProtKB:P58004};

Provider

SWISS-PROT

Sequence

Polypeptide 492 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sesn3	sestrin 3	31	101	3	4

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:189021 Lee JH, et al., Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 5;16(3):311-21
J:214946 Peng M, et al., Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell. 2014 Sep 25;159(1):122-33
J:232620 Tao R, et al., Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling. Diabetes. 2015 Apr;64(4):1211-23